Anti-thymocyte globulin induced non-cardiogenic pulmonary edema during renal transplantation

Hydrochlorothiazide-induced acute non-cardiogenic pulmonary edema.

We report the case of a 64 year-old male with non cardiogenic pulmonary edema episodes after oral administration of 12.5 mg of hydrochlorothiazide. In vitro immunologic study with basophil activation test and late cellular activation study (CD69 and production of interferon gamma) with chlorothiazide were performed, and no activation was observed. As a consequence, like in previous cases publis...

Aspirin-induced non-cardiogenic pulmonary edema.

Sir, Aspirin is a non-selective inhibitor of cyclooxygenase (Cox) enzyme, which inhibits production of prostaglandins. Several anaphylactic reactions have been reported in response to aspirin therapy, viz asthma, angioneurotic swelling, urticaria, fixed drug eruptions etc. We are reporting an unusual case of acute respiratory distress syndrome (non-cardiogenic pulmonary edema) caused due to hyp...

Non-Cardiogenic Pulmonary Edema

Non-Cardiogenic Pulmonary Edema

T he barrier between pulmonary capillaries and alveolar gas consists of a series of three anatomical layers with distinct structural characteristics. The cytoplasmic projections of the capillary endothelial cells represent the first layer of this barrier and overlap to form a continuous cytoplasmic tube. At the overlapping junctions of these cytoplasmic projections are clefts of varying sizes (...

Anti-thymocyte globulin induced thrombocytopenia.

Anti-thymocyte globulin is strongly reactive with platelets as measured by flow cytometric analysis. This reactivity appears to be independent of human leukocyte antigen (HLA) phenotype, is dose-dependent with saturation of platelet binding sites readily achieved with concentrations of horse anti-thymocyte globulin (ATG) at 0.25 mg per ml, and cannot be blocked with human anti-PLA1 antibody nor...